My current research focuses on investigating the effect of chronic alcohol exposure on development of liver cirrhosis progressing to liver cancer using novel mouse models of alcohol-mediated liver injury. Specifically, I am investigating the role of immune cells (macrophages, neutrophils and T cells) and their receptors during liver injury due to alcohol consumption using novel knock-out mouse models of liver disease. I am evaluating the signaling mechanisms within immune cells and intracellular proteins and their inhibitors to identify unique therapeutic targets altered by alcohol to enhance liver disease. While working as a research intern at Meharry Medical College, Nashville (TN) for a short time period (2015), I was involved in evaluating anti-carcinogenic effects of endothelins and soy peptides in breast cancer. I received my Ph.D. from Department of Immunopathology at PGIMER (India) in December 2014. Ph.D. research work focused on evaluating the immunomodulatory potential recombinant antigens of L.donovani in specific activation of macrophages. I showed that one of the antigen when used as an adjunct to the currently used drugs helped early parasite clearance at suboptimal doses of highly toxic chemotherapeutic drugs using experimental animal model.
|Research Interest :
My current research focuses on investigating the effect of chronic alcohol exposure on development of liver cirrhosis progressing to liver cancer using novel mouse models of alcohol-mediated liver injury. Research also includes evaluating heat shock protein inhibitors and their nanoformulations as therapeutic targets. The keywords which describe my research work are immunology, inflammation and organ damage, cancer, immune cells and their receptors, signaling pathways and therapeutic targets.
- Oncology Clinics and Research (ISSN: 2643-055X)
- International Journal of Clinical Case Studies and Reports (ISSN:2641-5771)
- Stem Cell Research and Therapeutics (ISSN:2474-4646)
- Journal of Renal Transplantation Science (ISSN:2640-0847)
- Ophthalmology Clinics and Research (ISSN:2638-115X)
- Journal of Forensic Research and Criminal Investigation
- Journal of Spine Diseases