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Neoadjuvant
chemotherapy (NAC) of rectal cancer has some advantages: 1) Whole body control
from the early stage of treatment; 2) Tumor reduction (favorable for
laparoscopic surgery); 3) No functional failure due to radiation.
In this
study, a total of 50 patients with rectal cancer, treated with NAC, were
examined. The pathological primary cancer area and the radiological cancer
volume reduction ratio were measured using CT and/or MRI imaging and the
donut-shaped measurement method. Immunostaining of cytokeratin AE1/AE3 was
performed to quantitatively measure the cancer cell mass in the largest section
of rectal cancer. Cytokeratin AE1/AE3-stained area (P=0.04), mitosis (P=0.0027)
and radiological donut-shaped images after NAC (P=0.010) were lower in the high
radiological cancer volume reduction ratio group compared with the low
radiological cancer volume reduction ratio group.
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