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Objective: This
research aims to evaluate the histopathological changes after pretreatment with
resatorvid against methotrexate induced-liver injury.
Methods: 28 male albino-wistar rats divided into random 4 groups (7 rats in
each). Control group: Rats left untreated. Vehicle pre-treated group: Rats were
administered dimethyl sulfoxide (DMSO) followed by methotrexate (MTX).
Methotrexate treated group: Rats left untreated then administered MTX.
Resatorvid pre-treated group: Rats were administered resatorvid followed by
MTX. 24 h after the end of treatment, the animals were sacrificed. Liver tissue
samples dissected out immediately and fixed in 10% formalin. The traditional
procedures (paraffin-embedded method) was used to prepare liver tissue for
microscopic evaluation by none alcoholic fatty liver disease (NAFLD) Activity
Score Components.
Results: Liver tissue sections of MTX-treated group show moderate-to-severe
steatosis of hepatic cells and micro- and macro- hepatocellular
fatty degeneration and giant fatty cysts with chronic inflammatory cells
infiltration. While liver tissue sections of the resatorvid pre-treated group
show moderate hepatic cellular fatty degeneration, with a decreased number of
fatty cysts chains and the inflammation disappeared.
Conclusion: Resatorvid hepatoprotective effect against MTX-induced injury was
promising throughout resolving the accompanying inflammation and partial
restoring histopathological fatty alterations.
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