Research Article
Doppler Vascularization of Uterine Fibroids According to Location
Sabar Butt*, Syeda Khadija, Syed Amir Gilani, Sadaf Ayesha and Mohammad Yousaf
Corresponding Author: Sabar Butt, Department of Radiological Sciences and Medical Imaging Technology, Sabari Ultrasound Training Institute, 411-A Ghulam MOHAMMAD Abad Faisal Abad, Lahore, Pakistan
Received: July 05, 2020; Revised: July 29, 2020; Accepted: July 27, 2020 Available Online: November 04, 2020
Citation: Butt S, Khadija S, Gilani SA, Ayesha S & Yousaf M. (2020) Doppler Vascularization of Uterine Fibroids According to Location. Int J Med Clin Imaging, 5(3): 227-231.
Copyrights: ©2021 Butt S, Khadija S, Gilani SA, Ayesha S & Yousaf M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Uterine fibroids are utmost common benign tumors sometimes they affect even after menopause. The estimated incidence of uterine fibroids is 20-40% in reproductive age. There are several factors that attributed to underlie the development and incidence of these common tumors, but this further corroborates their relatively unknown etiology.

Methods: A prospective case control study was carried out, at Sabiry Color Doppler Ultrasound Centre Faisalabad during November, 2015 to March, 2016 on a group of 100 Pakistani females, with clinical suspicions of uterine fibroids. Toshiba Nemio XG & Aplio 500 with 3.5-5 MHztransducer was used. Patients were scanned with adequately full bladder, Fibroids were identified, their sizes and location were evaluated and recorded. RI of the main feeding vessel of fibroids was calculated. The fibroids were divided into three types, according to their perfusion characteristics as follows: Type 1: Perfusion only at the periphery; Type 2: Central perfusion; Type 3: Both central and peripheral perfusion.

Results: The fibroids were found in 44 patients out of 100 females. They had different types of fibroids depending upon their location. Perfusion grading of the fibroids was done and R.I of feeding vessels was calculated. Both of the variables were correlated. The percentage of uterine fibroids were 18 (40.9%) sub-serous, 20 (45.4%) intra-mural, 5 (11.4%) sub-serous and intra- mural, 1 (2.3%) sub-serous pedunculated. The resistive index of feeding vessel of different fibroids ranges between 0.33-1.00. The perfusion grading of fibroids that is 29 (65.9%) for grade 1, 2 (4.6%) grade 2, 13 (29.5%) for grade 3.

Conclusion: The majority (73%) was found to be in the group of age (22-40) year, (33%), (20-30 years), and (31-40 years), 43% with the higher incidence of uterine fibroid being among the same age group. Among fibroids Intramural fibroids has higher incidence 45.4%. Ultrasound is of high values, useful and practical in evaluation of uterine masses patients. The correlation between grading and R.I is significant.

Keywords: Intra-mural, Perfusion, Resistive index, Sub-serous, Uterine fibroids
INTRODUCTION
Leiomyomas are most common and nonthreatening neoplasms of the uterus. They occur in 20-30% of females over age 30 years [1]. Myomas classified as intramural, confined to the myometrium; submucosal, protrusive into uterine cavity and displacing or distorting the endometrium; or subserosal, bulging from the peritoneal surface of the uterus. Intramural fibroids are more common than Submucosal fibroids, while submucosal myomas produce symptoms most frequently and also associated with infertility. Large size subserosal fibroids might be pedunculated extant as an adnexal mass. Cervical fibroids account forapproximately8% of all fibroids [2]. Fibroids are estrogen dependent, increase in size during an ovulatory cycle, as a result of unopposed estrogen stimulation, In pregnancy, even though about one half of all fibroids show little significant change during pregnancy [3]. In first trimester they are associated with increased risk of pregnancy loss, which is higher in patients with multiple fibroids than in those with a single fibroid [4]. Leiomyomas rarely develop in postmenopausal women, and increase in size in postmenopausal patients who are undergoing HRT; they stabilize or decrease in sizeafter menopause.

Tamoxifen has also been reported to cause growth in leiomyomas [5]. Sonographically, myomas have variable appearances, most often hypoechoic or heterogeneous in echo texture. Calcification may occur in fibroids, frequently appearing as focal areas of increased echogenicity with shadowing, or as a curvilinear echogenic rim, which may simulate the outline of a fetal head [6]. When fibroids undergo rapid growth, they tend to outgrow their blood supply, leading to degeneration, necrosis and producing areas of decreased echogenicity or cystic spaces within the fibroid [7]. This often during pregnancy, affecting about 7-8% of pregnant females with fibroids, it presents with pain over this area [8]. Submucosal fibroids are usually broad-based solid hypoechoic masses with an overlying layer of echogenic endometrium. Sonographically, the finding of a highly echogenic, attenuating mass within the myometrium is virtually diagnostic of this condition [9]. It is important to identify the lesion within the uterus so as not to confuse it with the more common, similar-appearing, fat-containing ovarian dermoid. Lipomatous uterine tumors are usually asymptomatic, they do not require surgery [10]. In this study we divided the fibroids into three types, according to their perfusion characteristics: Type 1: Perfusion only at the periphery; Type 2: Central perfusion; Type 3: Both central and peripheral perfusion.

The aim of this study was to aid in investigation and management of fibroids. Malignancies of uterine fibroids may be difficult to distinguish clinically and on grey scale, Doppler sonography is reliable now days. The diagnosis of uterine fibroids on color Doppler sonography makes it possible to differentiate between benign and malignant.

METHODOLOGY

This prospective case control study was carried out at Sabiry color Doppler ultrasound Centre Faisalabad between November 2015 to March 2016. The study was approved by the institutional review board and all women were informed about its purpose and gave their written consent to participate. One hundred females with clinical suspicion of uterine fibroids were included in this study. All ultrasound examinations were performed by the same examiner using a Toshiba Nemio XG & Aplio 500 with 3.5-5 MHz transducer. Myoma characteristics, such as location (submucous, intramural or subserous), topographic site (mostly anterior or posterior) were identified. In women with multiple fibroids, each myoma was measured and reference to its specific location. Demographic characteristics of patients including age, infertility, parity and body mass index (BMI) and menstrual cycle bleed were recorded. Statistical analysis was performed using the SPSS 20 software package. The normal distribution of quantitative variables age, parity, menstrual cycle bleed, BMI, size and blood flow in myoma were verified. Ultrasound examinations of myomas diameter were normally distributed and are reported as mean ±SD. Qualitative variables (location of myoma, topographic site of myoma) were expressed. The fibroids were divided into three types, according to their perfusion characteristics as follows:
Type-1: Perfusion only at the periphery;
Type-2: Central perfusion;
Type-3: Both central and peripheral perfusion.
RI of the main feeding vessel of fibroids was calculated.

RESULTS
The age of Patients having fibroids 22-59.29 (65.9%) married and 15 (34.1%) unmarried females out of 100 patients. Table 1 showed the fibroid type depending upon location which is 18 (40.9%) sub-serous, 20 (45.4%) intra-mural, 5 (11.4%) sub-serous and intra-mural, 1 (2.3%) sub-serous pedunculated (Figure 1). Table 1 showed resistive index of feeding vessels of different fibroids ranges between 0.33-1.00. Table 2 showed the perfusion grading of fibroid which is 29 (65.9%) for grade 1, 2 (4.6%) grade 2, 13 (29.5%) for grade 3 (Figures 2 and 3).
CONCLUSION

The majority 73% was found in the age group of 22-40 y, 33% in 20-30 y of age, and 43% in 31-40 y with the higher incidence of uterine fibroid being among the same age group. The correlation between grading and R.I is significant. Among fibroids, intramural fibroids have higher incidence 45.4%. Color Doppler values are useful in evaluation of uterine fibroids. Early detection of fibroids on ultrasonography can be treated by HRT (hormonal replacement therapy).
This is a potential cause of concern when fibroids are left untreated or managed conservatively, they can transform into malignancy.

DISCUSSION
Uterine fibroids are the benign tumors of the uterus and the most common indication for hysterectomy [11]. The most functional imaging modality for evaluating uterine fibroids is ultrasonography and the vascularity changes of fibroids can be easily assessed by color Doppler sonography [12]. Sonographically, the finding of a highly echogenic attenuating mass within the myometrium is virtually diagnostic of this condition [8]. Uterine fibroids can also be assessed by MRI but it is expensive, so majority of the patients with symptomatic uterine fibroids undergo sonographic evaluation [13]. It is important to identify the lesion within the uterus so as not to confuse it with the more common similar-appearing fat-containing ovarian dermoid. Aslipomatous uterine tumors are usually asymptomatic they do not require surgery [10]. The incidence of fibroids according to location in our study was 45.4% intramural, 40.9% subserosal, 11.4% subseroal and intramural and 2.3% subserosal pedunculated. Nieuwenhuis et al. [14] found 66 women having uterine fibroids with 5 Submucosal, 32 Intramural, and 29 Subserosal mean age 42 years. Ukwenya et al. found 7.8% subserosal, 5.1% submucosal, 4.5% pedunculated and 74.4% intramural. Sarkodie et al., reported 57.8% intramural, 4.4% submucosal and 55.6% in more than one layer [15,16]. The mean age of fibroid presentation in our study was 34 years and in studies and was 42, 31 and 31 years respectively [14,16,17]. In our study, 65.9% fibroids were in grade1 having peripheral flow, 4.6% grade-2 having central flow & 29.5% grade-3 having peripheral and central flow. 56 of U/S finding were found to be normal. The morphological criteria of “peripheral vascularity” were seen in 44 cases, being the criterion showing highest prevalence. Kurjak et al. [18] have shown increased blood velocity and decreased RI and PI in both uterine arteries in patients with uterine fibroids. Sladkevicius et al. [19] found that uterine myomas substantially affect blood flow velocity in the uterine arteries resulting PI values commonly
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