My primary research interest has been on innovative, multidisciplinary and highly-complex projects focusing on medicinal chemistry-driven drug design and delivery into the central nervous system. These activities have been conducted in successful and productive research collaborations with Laszlo Prokai, Ph.D., D.Sc, with translational medicine, and drug discovery in mind. Our projects involve pharmacokinetics, metabolism and drug distribution studies in early-phase drug discovery and the development of neuroactive/neuroprotective agents. We design and synthesize complex organic and peptide-based (pro)drug leads, and employ in silico predictions of physicochemical parameters important to select lead compounds for preclinical assessments, as well as biopharmaceutical analyses together with various neurochemical/pharmacological paradigms useful for monitoring of central delivery of agents.
|Research Interest :
medicinal and pharmaceutical chemistry, CNS drug design/delivery, prodrugs, translational research, neuroprotection, bioanalytical analysis, GC/LC-MS, MS-based proteomics