Abstract
30 Cases of Post-COVID-19 Vaccine Related Shingles
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The World Health Organization declared COVID 19 a pandemic on March 11, 2020. The novel coronavirus is characterized by high infectivity and severe morbidity and mortality. A race to design an effective vaccine was accomplished in record time with the developm ent and testing of two FDA approved vaccines: Moderna and Pfizer. Both vaccines, developed in under 12 months, utilize a new mRNA mechanism, and are the fastest vaccines ever created. Side effects such as injection site pain and flu like symptoms have been reported, however recently there have been a number of new cases of VZV reactivation (Herpes Zoster (HZ) a.k.a. shingles). The first case of Post COVID 19 vaccine shingles was seen at the Las Vegas Dermatology clinic on February 5, 2020, followed by 5 mor e cases seen in the clinic and 24 more who have contacted us through social media. In the literature, a single case of shingles following inactivated COVID 19 vaccination was reported in Turkey, 6 cases related to Pfizer vaccine in Israel, and another 10 c ases reported by the national COVID registry related to Moderna/Pfizer. Therefore, we present the largest case series of shingles post COVID 19 vaccination and emphasize the likelihood of a greater sum of undocumented post COVID 19 vaccine related shingles cases in the United States. It is still early in the course of vaccine distribution, and a direct relationship between COVID 19 vaccination and VZV reactivation is unproven. Immunomodulation related to COVID 19 vaccination and VZV reactivation is the susp ected etiology. With plans for mass vaccination underway, our findings will aid future epidemiological studies and further broaden the understanding of COVID 19 vaccination and VZV reactivation.
Keywords: Shingles, Herpes zoster, Varicella zoster virus, COVID 19, Coronavirus, Dermatology, Vaccine, Side effect, Adverse effects
Abbreviations: HZ:Herpes Zoster; VZV: Varicella Zoster Virus
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