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Diabetes is mainly a metabolic disorder while Alzheimer’s disease is a neurodegenerative disease (AD). Diabetes mellitus is mainly specified by impaired insulin signaling and increased blood glucose levels. AD on the other hand is one of the most common causes of dementia and is characterized by amyloid beta plaques and neurofibrillary tangles in the brain. Clinical data reveals that patients suffering with diabetes are more vulnerable to Alzheimer’s AD. However, the exact correlation between the two diseases is still obscure. The specific markers which may denote the link between the two pathologies have not been identified yet. Interestingly, several metabolic studies have pointed out towards indirect pathophysiological links between diabetes and AD. One of the major links among others is the insulin signaling pathway which is found impaired in both the diseases. Abnormal protein aggregation, mitochondrial dysfunction and ER stress are some of the other clinical pathologies common between the diabetes and AD. This review focuses on bringing out the various possible molecular links between AD and Diabetes to create an understanding for identifying potential biomarkers and better treatment strategies for the two diseases.
Keywords: Metabolic disease, Neurodegeneration, Insulin, Amyloid beta, Molecular link
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