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Nocardiosis is a
disease caused by a type of bacteria that is found in the environment,
typically in standing water, decaying plants and soil. These bacterial species
belong to the genus Nocardia and considered to be opportunistic pathogens.
Nocardiosis is a common opportunistic infection found in Patients both
immunocompromised and immunocompetent, cancer or on certain medications.
Pulmonary Nocardiosis shows clinical symptoms similar to Pulmonary
Tuberculosis. Bronchopulmonary lavage has also provided fresh dimension for the
investigation of pulmonary nocardia and other disorders.
Keywords: Nocardia, Pulmonary Nocardiosis, Bronchopulmonary lavage
INTRODUCTION
Nocardia is aerobic
actinomycetes group of bacteria which are gram-positive bacilli showing
branching filamentous forms, are non-spore forming and mildly acid-fast bacteria
[1]. These bacteria are saprophytic and are found in soil and water [2].
Pulmonary
infection with Nocardia spp. show
clinical symptoms similar to those suspected with pulmonary tuberculosis
(fever, cough, chest pain, night sweats, weight loss and pneumonia) [3,4].
Infections with Nocardia spp. usually
occur in individuals with weakened immune system and can include patients
suffering from diabetes, malignancies, HIV/AIDS, lung disorders like pulmonary
alveolar proteinosis (plugged lung air sacs), individuals with connective
tissue disorders, chronic alcoholism, transplant patients and patients on
corticosteroid therapy. It has been noted that more than 60% of human
nocardiosis occurs in immunocompromised individuals and that males are more
prone to infection than females (3:1) [4-7] and immunocompetent [8-11]
individual was reported recently in the literature. Previous study has also
elaborated on the types of radiological findings in pulmonary nocardiosis that
include consolidation of the lungs, presence of nodules and masses, pleural
effusion and extension of lung infection towards the chest wall resulting in abscess
[12-15].
Bronchopulmonary lavage (BAL) has provided a
fresh dimension for the investigation of pulmonary disorders. BAL fluid may be
analysed for cells and chemical mediators in the diagnosis and also serially
for the management of several granulomatous Disorders including sarcoidosis,
extrinsic allergic alveolitis, chronic beryllium disease, talc granulomatosis,
tuberculosis, Langerhans' histiocytosis-x and Crohn's disease [16]. It may also
provide information in fibrosing alveolitis, collagen vascular disease,
occupational and drug-induced lung disease, acquired immune deficiency
syndrome, bronchial asthma, neoplasia, transplantation, pulmonary alveolar
proteinosis and eosinophilic lung disease. This study is planned to analyses
the value of BAL in Nocardia infection.
MATERIALS AND
METHODS
The medical
records of patients with a diagnosis of nocardiosis maintained by
Unique Hospital identification
RESULTS
Over the study period, there were 13 cases of
nocardiosis at Delhi Heart Institute and Multispeciality Hospital, Bathinda
(Punjab), India. Data of 13 cases were collected. The age, sex distribution
(male/female 3:1) and underlying diseases (found in 80% of cases) are shown in Table 1. Immunosuppressive agents (either
corticosteroids or methotrexate treatment) having connective tissue disease
used in 61.5% of cases followed by chronic lung disease (15.3%) and diabetes
mellitus (15.3%) and Grave’s disease was also found in one case.
The common clinical findings were fever,
cough and hemoptysis (Table 2). Only
15.3% of patients had fever less than one week before presentation. Septic
shock was documented at initial presentation in three cases.
Chest radiographs of all 13 cases were
reviewed with a radiologist. The abnormal findings are summarized in Table 3. The common abnormalities were
alveolar infiltrates (39.1), patchy opacities (36.9%), cavity lesion (21.7%)
reticulo-nodular infiltration (17.4%) were found either alone or concurrently
with infiltration.
DISCUSSION
Nocardiosis is a common opportunistic
infection in immune compromised hosts that can cause serious or disseminated
disease. More than 60% of all reported cases of nocardiosis are associated with
pre-existing immune compromise ranging from alcoholism and diabetes to organ
transplantation and AIDS. Persons requiring long-term corticosteroid or
methotrexate treatment are also at risk with underlying diseases.
Pulmonary disease is the predominant clinical
finding followed by connective tissue disease (61.5%), which is similar to
other reports [18].
Whereas chest
pain is (30.7%) cough, expectorate and headache has shown (23%) followed by
dyspnea (15.3%). No difference between alveolar and reticulonodular or
interstitial pattern of pulmonary infiltration was found. Although cavitation
was common in pulmonary nocardiosis (21.7%) found in this study.
CONCLUSION
Nocardiosis is
still a major problem in immune compromised hosts. Pulmonary infection was the
predominant manifestation. Positive smears of Nocardia were seen in only 60% of
cases, which may have resulted in missed or Delayed diagnosis in the remainder.
Therefore, nocardiosis should be suspected in immune compromised and
Methotrexate-treatment patients, whereas bronchopulmonary lavage has also
provided a fresh dimension for the investigation of pulmonary disorders.
1.
Gordon MA (1985) Manual of Clinical Microbiology.
Washington, D.C: American Society for Microbiology. Aerobic Pathogenic
Actinomycetaceae, Chapter 23: 249-262.
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Conville PS, Witebsky FG (2007) Manual of Clinical
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other aerobic actinomycetes, pp: 515-542.
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