Case Report
Organ Sparing Surgery for Carcinosarcoma of the Urinary Bladder Diverticulum
Goran Stimac*, Monika Ulamec and Marijana Jazvić
Corresponding Author: Goran Stimac, MD, PhD, Urologist, Clinical Department of Urology,
Received: December 12, 2017; Revised: February 21, 2018; Accepted: December 20, 2017
Citation: Stimac G, Ulamec M & Jazvić M (2018) Organ Sparing Surgery for Carcinosarcoma of the Urinary Bladder Diverticulum. Int J Med Clin Imaging, 2(1): 27-30
Copyrights: ©2018 Stimac G, Ulamec M & Jazvić M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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Keywords: Bladder Diverticulum, Carcinosarcoma, Computed Tomography, Diverticulectomy, Chemotherapy, Radiotherapy

Clinical Presentation


A 53-year-old man presented in our department with symptoms of bladder irritation and painless hematuria. Laboratory was unremarkable, but urinalysis revealed microscopic hematuria. Urinary cytology revealed porely differentiated tumor. The cytogram phase of excretory urography showed large extrinsic impression of the left side of  the urinary bladder  (Figure 1) A CT scan of the pelvis (Figure 2) showed an irregular contrast enhancing tumor mass filling bladder diverticulum and measuring 6 cm in diameter. The patient underwent transvesical diverticulectomy along with tumor mass and regional pelvic lymph node dissection. Pathology identified a 6x5 cm intradiverticular solid tumor and established the diagnosis of carcinosarcoma with extension to the perivesical fat (Figure 3) The lymph nodes and resected margins were negative of tumor. The patient did well postoperatively, and his symptoms completely resolved. Due to poor prognostic features of resected tumor, the oncology board decided to treat the patient with adjuvant chemotherapy and radiotherapy. Six months postoperatively pelvic CT scan (Figure 4) and cystoscopy were unremarkable.



The majority of bladder cancers originate from the urothelium (1,2).  The overall reported incidence of neoplasm arising in urinary bladder diverticulum varies from 2.9% to 4.0% and these neoplasms have a poorer prognosis than tumors arising within the urinary bladder lumen (2,3). Most intradiverticular tumors are urothelial carcinomas and only a minor portion is the other histologic type (1,2). Carcinosarcoma is an unusual neoplasm that shows a mixture of malignant epithelial and malignant mesenchymal components (4,5). Chronic infection, irritation, smoking, cyclophosphamide, and radiotherapy are considered to play a role in the etiology of carcinosarcomas (4). Intradiverticular carcinosarcomas, though rare, carry a poor prognosis due to the aggressiveness of the tumor and early invasion. The bladder diverticulum, lacking a muscular wall, is easily infiltrated by the tumor, resulting in perivesical extension as seen in our case. This necessitates early diagnosis and aggressive treatment in these tumors. There are no standard guidelines for management of this rare tumor type. Recently, radical surgery plus various combinations of neoadjuvant or adjuvant chemotherapy and/or radiotherapy has been suggested by some authors (4,5). However, the outcomes have been extremely variable and inconsistent (5).


Our patient was treated successfully and remained free from the disease de­spite the non-radical approach

Nuwahid F, German K, Campbell F, Stephenson T. Carcinosarcoma in a bladder diverticulum. Urology 1994; 44: 775–8.

2. Knappenberger ST, Uson AC, Melicow MM. Primary neoplasms occurring in vesical diverticula: a report of 18 cases. J Urol. 1960;83:153–159.

3. Stimac G, Knežević M, Grubišić I, Soipi S, Tomas D, et al. A rare case of squamous cell carcinoma in urinary bladder diverticulum successfully treated by bladder-sparing surgery. Acta Clin Croat. 2015 Sep;54(3):363-6.

4. Halachmi S, DeMarzo AM, Chow NH, Halachmi N, Smith AE, et al. Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin. Eur Urol. 2000; 37:350-7.

5. Cheng CW, Ng MT, Cheung HY, Sun WH, Chan LW, et al. Carcinosarcoma of the bladder diverticulum and a review of the literature. Int J Urol. 2004 Dec; 11(12): 1136-8.