Presently Packaging plays a significant role for New Drug discoveries. The process of selecting materials and the type of packaging also offers an opportunity for the Packaging scientist to look for new biological delivery choices. Most injectable protein products were supplied in some sort of glass vial, prefilled syringe, and cartridge. That product having high Ph content there is a chance of “delamination “from inner surface of glass vial. With protein- based drugs, the biggest issue is the effect of packaging derivatives on the protein’s three- dimensional and surface structure. These are any effects that relate to denaturation or aggregation of the protein due to oxidation or interactions from contaminants or impurities in the preparation. The potential for these effects needs to be carefully considered in choosing the container and the container closure system to avoid putting patients in jeopardy.