Case Report
Dural Metastasis of Glioblastoma: Case Report
Sidki Kenza*, Horache Kenza, Ez-Zaky Sara, Omor Youssef and Latib Rachida
Corresponding Author: Sidki Kenza, National Oncology Institute of Rabat, Morocco.
Received: March 01, 2024; Revised: March 15, 2024; Accepted: March 18, 2024 Available Online: March 21, 2024
Citation: Kenza S, Kenza H, Sara E-Z, Youssef O & Rachida L. (2024) Dural Metastasis of Glioblastoma: Case Report. J Neurosurg Imaging Techniques, 9(1): 587-590.
Copyrights: ©2024 Kenza S, Kenza H, Sara E-Z, Youssef O & Rachida L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Metastases extra neural stemming from are a rare progression of glioblastoma, with an incidence of 0.4-0.5% of all glioblastoma cases. The locations can be extra neural, such as leptomeninges and dural venous sinuses, extra neural and extracranial, such as solid organs and lymph nodes, yet in this study, we report the case of a patient previously diagnosed with glioblastoma presenting extramedullary dural metastases. The lesson learned from this case is to look for early craniospinal metastasis in GBM patient.

Keywords: Glioblastoma, Dural, Metastasis, Extra neural

Abbreviations: MRI: Magnetic Resonance Imaging; SNC: Society of Nutrition Counselors

Glioblastoma The occurrence of dural metastasis from glioblastoma is relatively rare. It's estimated that dural metastases occur in less than 5% of cases involving secondary intraspinal locations, and among these, only about 3.5% are strictly intramedullary.  Glioblastomas typically tend to metastasize within the central nervous system rather than outside the brain or spinal cord [1]. And when they do spread, dural involvement is a less common manifestation compared to other sites within the CNS [2]. However, cases of spinal locations have been reported, typically situated outside the spinal cord, as seen in our case study.


A 73-year-old patient previously diagnosed with right glioblastoma reported intensified back pains, particularly in the lumbar region. A spinal MRI was conducted to identify imaging anomalies that could explain these symptoms. The MRI revealed secondary metastases, both bone-related and extramedullary intradural, localized at the level of the spinal cord (L1-L2) and dorsal vertebrae (D9 and D11). These areas exhibited unusual signals on MRI images following gadolinium injection (Figures 1-5).


Intradural metastases constitute only a small fraction of secondary spinal localizations, typically situated outside the spinal cord. Only 3.5% are strictly intramedullary, attributed to the aggressiveness of glioblastoma within the subarachnoid spaces [3]. In contrast, intradural metastases seem to follow a different path of spread through cerebrospinal fluid (CSF). These cases remain rare, primarily due to the short lifespan associated with this type of intradural metastasis stemming from glioblastoma. Surgical removal of these spinal metastases is often decided based on patient symptoms and the lesion's location [4-5]. Unfortunately, patient survival is reduced, ranging from a few months to two years, with a discouraging prognosis.


Extracranial metastases of glioblastoma multiforme (GBM) are rare due to the short survival experienced by the patients [6]. Spinal MRI remains pivotal for diagnosis, and the recommended treatment involves surgical resection and postoperative radiotherapy, accompanied by concurrent and adjuvant temozolomide chemotherapy, remain the standard of care [5].

  1. Seo Y, Cho WH, Kang DW, Cha SH (2012) Extra neural Metastasis of Glioblastoma Multiforme Presenting as an Unusual Neck Mass. J Korean Neurosurg Soc 51(3): 147-150.
  2. Lettau M, Jedrusik P, Laible M (2012) Dural Metastases of a Glioblastoma. Clin Neuroradiol 23(4): 323-325.
  3. Terheggen HG, Müller W (1977) Extra cerebrospinal metastases in glioblastoma. Eur J Paediatric 124: 155-164.
  4. Ray A, Manjila S, Hdeib AM, Radhakrishnan A, Nock CJ, et al. (2015) Extracranial metastasis of gliobastoma: Three illustrative cases and current review of the molecular pathology and management strategies. Mol Clin Oncol 3(3): 479-486.
  5. Lauren LH, Daniel HM, Tasneem K, Neema,Byron CM, et al. (2018)Treatment of a glioblastoma multiforme dural metastasis with stereotactic radiosurgery: A case report and select review of the literature. J Clin Neurosci 48: 118-121.
  6. Marcelo LVC, Marcos VCM (1992) Metastasis from glioblastoma multiforme: A meta-analysis. Rev Assoc Med Bras 65(3): 424-433.