Abstract
Effects of ABCB1 Gene Polymorphism on Toxicity of Taxane Based Chemotherapy in Bangladeshi Triple Negative Breast Cancer Patients
47
Views & Citations10
Likes & Shares
Background: Triple-negative breast cancer (TNBC) poses a significant therapeutic challenge due to its aggressive nature and limited treatment options. There is a chance of developing toxicities with Taxane-based treatments and these can differ from person to person. Drug response and toxicity may be influenced by variations of ABCB1 gene.
Objectives: To assess the impact of ABCB1 (rs1045642) polymorphisms on the toxicity of Taxane based chemotherapy in Bangladeshi triple-negative breast cancer patients.
Methods: 100 female patients with breast cancer who had received docetaxel or paclitaxel containing neoadjuvant chemotherapy were included in this study. The Taxane-induced toxicity during the treatment was evaluated. Genetic polymorphisms were detected with by PCR-RFLP technique.
Results: ABCB1 (rs1045642) polymorphism was found to be significantly associated with chemotherapy-induced anemia, neutropenia and gastrointestinal toxicity. Patients with the “TT” genotype of the ABCB1 (rs1045642) gene had a significantly higher risk of developing Anemia (OR = 4.40, 95% CI = 1.06 to 18.09, p = 0.0400) compared to those with the 'CC' genotype. Additionally, patients with the 'TT' and 'CT plus TT' genotypes of the ABCB1 (rs1045642) gene had a significantly higher risk of developing Neutropenia and Gastrointestinal Toxicity compared to those with the 'CC' genotype (OR = 4.38, 95% CI = 0.99 to 19.35, p = 0.0511 and OR = 3.76, 95% CI = 0.95 to 14.87, p = 0.0581 and OR = 4.33, 95% CI = 1.02 to 18.25, p = 0.0457; OR = 3.63, 95% CI = 1.05 to 12.55, p = 0.0416). This study did not find any significant relationship between leukopenia and the ABCB1 (rs1045642) gene variant.
Conclusion: Genetic variations in ABCB1 (rs1045642) may influence the toxicity of Taxane-based chemotherapy in Bangladeshi TNBC patients. This study sheds light on pharmacogenomic markers for personalized Triple-negative breast cancer treatment, optimizing efficacy and minimizing adverse effects.
Keywords: ABCB1, P-glycoprotein, Polymorphisms, Breast cancer treatment, Taxane-based chemotherapy, Drug resistance
QUICK LINKS
- SUBMIT MANUSCRIPT
- RECOMMEND THE JOURNAL
-
SUBSCRIBE FOR ALERTS
RELATED JOURNALS
- Journal of Biochemistry and Molecular Medicine (ISSN:2641-6948)
- Proteomics and Bioinformatics (ISSN:2641-7561)
- Advances in Nanomedicine and Nanotechnology Research (ISSN: 2688-5476)
- Food and Nutrition-Current Research (ISSN:2638-1095)
- Journal of Veterinary and Marine Sciences (ISSN: 2689-7830)
- Journal of Microbiology and Microbial Infections (ISSN: 2689-7660)
- Journal of Genetics and Cell Biology (ISSN:2639-3360)
