Abstract
Plectranthus Spp: A Key Source of Lead Molecules for Cancer Research
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Natural products obtained from medicinal plants are widely recognized as an important source of new therapeutic molecules with potential use in several serious diseases, including cancer. The Plectranthus genus is used in traditional medicine due to its potential to treat several illnesses. Diterpenoids are bioactive molecules widely found in Plectranthus spp., and have a broad spectrum of biological activity, namely anticancer properties.
In this work, it will be described several approaches using these bioactive led molecules and examples such as Parvifloron D from P. ecklonii, dehydroroyleanone from P. madagascariensis, and P. grandidentatus, and, Coleon U from P. mutabilis will be described. These lead molecules can be further used for drug development and a hit molecule is the patented diterpenoid benzoylroyleanone (RoyBz). The RoyBz was prepared using Roy as starting material. RoyBz potently inhibited the proliferation of colon cancer cells by inducing a PKCdelta-dependent mitochondrial apoptotic pathway involving caspase-3 activation. The results point to promising activators of PKCs with high potency and isoform-selectivity that may emerge from the exploitation of this new family of abietane diterpenoids.
Keywords: Plectranthus genus, Biological activity, Anticancer properties
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