Review Article
Psoriasis Arthritis and Elderly Patients
Kassi K*, Kouamé K, Vagamon B, Allou A, Kouassi A, Kourouma HS, Kouassi YI, Sangare A and Yoboue-Yao P
Corresponding Author: Kassi Komenan, MD, Department of Dermatology and infectiology, training and research unit of Medical sciences, University of Felix Houphouet Boigny of Abidjan
Received: June 24, 2017; Revised: June 29, 2017; Accepted: June 26, 2017
Citation: Kassi K, Kouamé K, Vagamon B, Allou A, Kouassi A, et al. (2017) Psoriasis Arthritis and Elderly Patients 151-154.
Copyrights: ©2017 Kassi K, Kouamé K Vagamon B, Allou A, Kouassi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Introduction: Psoriatic arthritis (PsA) is a heterogeneous disease that can involve a patient's peripheral and axial joints, entheses, skin and nails. PsA is more a gressive in geriatric patients with several co-morbidities. Systemic therapies that are indicated in PsA seem to have many side effects in geriatric patients.

Method: It was a systematic literature review via electronic search using Medline, Pubmed,  Pubmed  central,  Cochrane, Google scholar, web of science and embase, ACR reports.

Comment: PsA is a rare form of psoriasis. Genetic predisposition to psoriasis follows a multifactorial pattern. In senegal, a study conducted on 35 cases of psoriatic arthritis reported a family history in 57% of cases. With HIV epidemic, numerous reports of HIV infected patients with psoriatic arthritis were published. These genetic components and the Environmental  factors interact to lead to immune dysregulation. Recent studies on psoriatic arthritis suggested that IL-6 is necessary for production of antibodies specific for joint components (autoimmune phase) and TNF is necessary for generation of arthritis (inflammation phase). Psoriatic arthritis is traditionally defined as an inflammatory, rheumatoid factor-negative arthritis associated with psoriasis.

Due to the absence of specific biological markers for psoriatic arthritis, many tools have been recommended to diagnose PsA. Before the introduction of biotherapy, sulfasalazine and methotrexate were the most  used,  and  study drugs  in  peripheral forms of PsA patients. Biological therapies, mainly TNF inhibitors, have greatly improved the ability of clinicians to treat the various manifestations of PsA. Their side effects limited their use in geriatric patients, due to senescence, and co-morbidity associated with.

Conclusion: PsA impact negatively their quality of life and self care. Systemic treatments like TNF-antagonists that are recommended to treat PsA have many side effects in this population group. Therefore, it should carefully be used.


Key words: Psoriasis, Psoriatic arthritis, Clinic and Diagnosis, Management


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