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Background:
Striae Distensae
(SD), represent linear dermal scars with epidermal atrophy of the epidermis
that may cause significant cosmetic problems, especially in young women.
Objective:
To study the efficacy and safety of MnRF in the
treatment of striae distensae.
Materials
and method: A total of 20
patients (male: 7, female: 13) aged between 18-40 years with SD attending the
dermatology OPD, received four sequential MnRF treatments with an interval of 4
weeks between each session. A detailed history, general physical and dermatological
examination of the striae, along with photographs, of each patient was taken
before and after the procedure with emphasis on striae distensae. Clinical
assessment of improvement of striae was done based on Global Improvement Scale
at their first visit and at the end of 1 month after the last session. In
addition, patients were asked to provide their opinion on improvement of striae
using the patient satisfaction score.
Results: Out of our 20
patients (n=20), subjected to 4 consecutive MnRF sessions, four weeks apart, 6
patients showed ‘marked improvement’, while 12 patients showed ‘moderate
improvement’ and 2 had ‘minimal improvement’. According to the patient
satisfaction score, 6 out of the twenty patients were ‘very satisfied’ with the
treatment, while 8 were ‘satisfied’ and 6 were ‘slightly satisfied’ with their
treatment outcome. No significant adverse effects were reported.
Conclusion: In our study, MnRF
was found to be a safe and effective modality in the treatment of striae
distensae.
Keywords: Psychological, Microneedling fractional,
Hyperpigmentati, Striae distensae
INTRODUCTION
Striae Distensae (SD) or stretch marks are
common disfiguring skin condition characterized by linear atrophic plaques that
are initially erythematous (striae rubra) and overtime become progressively
atrophic and hypopigmented (striae alba) [1]. Although, SD do not pose any
serious medical problems but may have significant aesthetic and
psychological/psychosocial impact on affected patients, especially in young
women [2]. Improving the appearance of SD, particularly striae alba, has always
been a challenge, owing to the limited availability of efficacious and low risk
treatment options. A variety of treatment modalities have been advocated for
the treatment of SD, including topical preparations like topical tretinoin
(0.1%), trofolastin cream, peels such as trichloroacetic acid (13%, 20%, 30%)
and glycolic acid (50%, 70%) peels. Lasers and light based devices like 308 nm
excimer laser, 585 nm pulse dye laser 1064 nm Nd-Yag laser,
ablative/non-ablative lasers and intense pulse light have also been tried for
treatment of SD, but, with inconsistent results [3]. However, no definitive
gold standard treatment modality for the treatment of SD has been determined
till date and hence, there is a need for newer therapeutic modalities that are
more efficacious and safe with minimal downtime.
A recently developed minimally invasive novel
technique is microneedling fractional radiofrequency (MnRF). It has been used
to treat various dermatological indications like wrinkles and
atrophic/hypertrophic scars. Microneedling fractional radiofrequency treatment
has demonstrated significant clinical improvement in acne scars, open pores and
skin rejuvenation [4]. The histopathological analysis of SD, especially striae
alba, being similar to a scar [5], MnRF provides a very promising option. With
extensive review of
MATERIALS AND
METHODS
Participants
A total of twenty randomly selected
patients(M:F=1:2), aged between 18-40 years, with Fitzpatrick skin type III-V,
having striae over the arms, abdomen, back, thighs, chest and gluteal region,
attending the OPD at the Department Of Dermatology, Venereology and Leprosy,
Adichunchanagiri Hospital and Research Centre, B.G. Nagara, Nagamangla Taluk,
Mandya District, were enrolled in the study. Approval was obtained from
institutional ethical committee and a written informed consent was taken from
all the patients before enrolling them in the study. A detailed dermatological
examination of the striae along with photographs of each patient was taken
before and after the procedure with emphasis on striae distensae.
Pregnant/lactating women and patients with
active infections like Herpes, Type I/II were excluded from the study. Patients
with history of photosensitive disorders like lupus erythematosus,
dermatomyositis or who are on anti-coagulants, anti-platelet therapy,
immunosuppressive drugs and platelet disorders were not considered for the
study.
Patients with Cushing’s
disease/Ehlers-Danlos syndrome or patients with history of propensity for
keloid formation and vitiligo were excluded.
Patients with implants, like pacemaker or
cochlear implants or who had received treatment for laser skin resurfacing in
the past 6-12 months on the striae were also not considered.
Treatment
Microneedling
fractional radiofrequency device and treatment protocol: Patients with striae distensae
were subjected to receiving four sequential microneedling radiofrequency (DERMA
INDIA MR 16-2SB) treatments with an interval of 4 weeks between each session.
The energy delivery system consists of a disposable tip with 25 gold-plated
insulated microneedle electrodes with a maximum energy output of 50 W. The
depth of the needle can be adjusted from a minimum of 0.5 mm to a maximum of
3.5 mm. When the needles reach the pre-defined insertion depth, the RF is
emitted selectively heating the dermis while sparing the epidermis. The time of
needles being out was 450 ms and the time difference of radiofrequency and
needles being out were 10 ms for each session.
Prior to each treatment session, EMLA cream
(Lignocaine 2.5% and Prilocaine 2.5%) was applied to the targeted regions of
striae distensae for 40 min followed by gentle cleansing. The procedure area
was painted with povidine iodine and cleant with 70% isopropyl alcohol as a
disinfectant, using sterile precautions.
In each session, two passes were administered. Penetration depth was
individualized for each stria, ranging from 1.5 mm to 2.5 mm. Disposable micro
radiofrequency needles were used for every patient in each session.
Post procedure, the sites were wiped gently with cold water and an ice
pack was applied for 5 min to alleviate discomfort and minimize swelling.
Patients were advised to apply hyaluronic acid based emollients. Any
post procedure erythema was treated with topical steroid antibiotic cream
provided by the investigator and post procedure pain was managed with
non-steroidal anti-inflammatory drugs
Evaluation
Assessments were made by photographing the
striae by a digital camera (SONY CYBERSHOT). Objective clinical assessment was
carried out by comparing before and after photographs using the Global
Improvement Scale, viz. Grade 0- Worsened, Grade I- Minimal improvement
(0-30%), Grade II- Moderate improvement (31-50%), Grade III- Marked improvement
(51-80%), Grade IV-
Near total improvement (>81%) at baseline, that is their first visit and 1
month after the last session.
In addition, the patients were asked to
provide their opinion about the improvement of striae, using the patient
satisfaction Visual Analogue Scale (0- Not satisfied, 1- Slightly satisfied, 2-
Satisfied, 3- Very satisfied, 4- Extremely satisfied) at the end of one month,
after 4 treament sessions.
Patients were assessed for side effects, such
as tear, erythema, pain, burning, bleeding and post inflammatory
hyperpigmentation. One month after the final session, patients were again
evaluated for any possible side effects.
Data collected was entered into Microsoft
Excel 2016 and analyzed using SPSS 20.0. Descriptive statistics was expressed
using mean and SD. For test of significance, paired t test and chi square test
were used. P value<0.05 was considered significant at 95% confidence
interval.
RESULTS
Out of the 20 patients (n=20) (M:F=1:2),
subjected to 4 consecutive MnRF sessions, four weeks apart, 6 patients showed
marked improvement, while 12 patients showed moderate improvement and 2
demonstrated minimal improvement. According to the patient satisfaction score,
6 out of the twenty patients were ‘very satisfied’ with the treatment, 8 were
‘satisfied’ and 6 were ‘slightly satisfied’.
Amongst the three groups of outcome, viz.
minimal improvement, moderate improvement and marked improvement groups; no
conclusive significant difference could be established between the minimal and
marked groups using the ANOVA test (p=0.059). However, while the
analysis of variance between the minimal group and moderate group (p=0.0152)
and moderate group and marked group (p=0.0154) showed a significant
difference.
In a few patients, post procedure erythema
was present, which was transient and subsided eventually. There were no
significant adverse effects reported (Figure
1).
DISCUSSION
Striae distensae, commonly referred to as
stretch marks, was described as a dermatological entity in 1889 [6]. It is a
common disfiguring skin condition characterized by linear smooth bands of
atrophic skin, appearing in areas of stretching due to dermal damage. They tend
to occur in areas of maximum stretching and initially develop opposite to the
skin tension lines [7]. It is found in both genders, across all races and is
usually located on the gluteal region, thighs, knees, calves, and lumbo-sacral
areas. A genetic predisposition is presumed, as SD has been reported in
monozygotic twins [1]. It has been postulated that, infection/inflammation
trigger the release of “striatoxin” that damages tissue and creates linear
atrophic depressions [8]. Although, SD do not pose any serious medical problems
but may have significant aesthetic and psychological/psychosocial impact on
affected patients, especially in young healthy women.
Most commonly, striae develop during
pregnancy, followed by in adolescence, rapid weight gain/loss, obesity,
prolonged use of systemic and topical corticosteroids and Cushing’s syndrome or
Marfan syndrome. Females are 2.5 times more susceptible to develop SD than
their male counterparts [3].
Histologically, striae are similar to scars,
but the lesions in striae distensae mature from striae rubra to stria alba. The
natural evolution of striae is from red/purple raised wavy lesion to white
atrophic lesion with a wrinkly texture. In striae rubra, lesions are deep with
superficial perivascular lymphocytic infiltrate. With time, reticular dermis
collagen bundles get stretched parallel to the skin, causing flattening of the
epidermis along with elongation of the rete ridges [4]. This is followed by
loss of collagen and elastic fibres in the dermis. Also, messenger RNA
expression of collagen, elastin and fibronectin gene is markedly reduced in SD [9].
In early stages, inflammatory changes are less conspicuous, with elastolysis accompanied by
mast cell degranulation, followed by activated macrophages that envelope
fragmented elastic fibres. In later stages, the dermal collagen is layered in
thin eosinophilic bundles oriented in straight lines [1].
Various topical
agents have been advocated in the management of striae. Tretinoin and retinoic
acid have been found to be useful in several studies. In early SD, it is
believed to act upon by stimulation of fibroblasts leading to increase tissue
collagen levels.
Combination of tretinoin and glycolic acid, or a combination of glycolic acid
and ascorbic acid, shows some improvement in striae rubra [7]. Hyaluronic acid is also found to be
effective in SD as it increases collagen production. Other agents
used with varying success are trofolastin (Centella
asiatica), silicone, glycolic acid, ascorbic acid, alphasria, bio-oil
fortified with vitamin C/E, topical retinoids, and peels like TCA/salicylic
acid peels [10]. Microderm abrasion has a possible stimulatory effect on Type I
procollagen formation.
Several lights based and laser modalities have
been implicated. The usefulness of these sources lie in their ability to induce
changes in collagen and elastin, as well as delivering energy that selectively
target oxyhemoglobin in dilated vessels of striae rubra [8]. Ablative lasers of wavelength more than
1000 nm are readily absorbed by tissue water, results in cell vaporization,
tissue heating and remodeling. The
commonly used ablative lasers for SD are CO2 (10,600 nm) and Er:YAG
(2940 nm). Non ablative lasers like Erbium glass laser has also been used for
fractional photo thermolysis [1]. Generally, repetitive treatments (4-6
sessions) are required.
Other lasers like Pulse dye laser, 308 nm eximer laser, Nd:YAG 1064 nm and
diode laser have been tried in the treatment of SD [8]. In spite of availability
of various treatment modalities, the results and outcomes in SD are
unsatisfactory; hence, there is a need for a newer modality which is more
efficacious and safe with minimal downtime.
A recently developed minimally invasive novel
technique is microneedling fractional radiofrequency. In MnRF, microneedles
penetrate into skin with minimal injury to epidermis and once within the
dermis, radiofrequency energy is delivered through needles. The heat generated
by the resistance offered to passage of radiofrequency energy causes dermal
remodeling, neoelastogenesis and neocollagenogenesis resulting in dermal
thickening and skin rejuvenation [11]. The mechanism of action is related to
the fact that water, melanin, collagen, dermal microvasculature can absorb energy
from the device producing a bulk heating effect to release growth factors like
VEGF, PDGF, EGF, TGF beta resulting in dermal remodeling [4].
Our data showed that, MnRF induced clinical
improvement of SD without causing serious side effects. This, to the best of
our knowledge, with extensive review of literature is the first study of its
kind using microneedling radiofrequency in the treatment of SD that showed
statistically significant improvement in the texture and size of striae in the
Indian population.
CONCLUSION
In conclusion, MnRF could be an effective
treatment for striae distensae, resulting in significant reduction in the
appearance and width of SD without serious adverse effects.
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Singh G,
Kumar LP (2005) Striae distensae. Indian J Dermatol Venereol Leprol 71:
370-372.
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and evidence-based evaluation of prophylaxis and treatment. Br J Dermatol 170:
527-547.
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ML, Baumann LS, Elsaaiee LT (2009) Striae distensae (stretch marks) and
different modalities of therapy: An update. Dermatol Surg 35: 563-573.
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Ryu HW,
Kim SA, Jung HR, Ryoo YW, Lee KS, et al. (2013) Clinical improvement of striae
distensae in Korean patients using a combination of fractionated microneedle
radiofrequency and fractional CO2 laser. Dermatol Surg 39:
1452-1458.
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Atwal GS,
Manku LK, Griffiths CE, Polson DW (2006) Striae gravidarum in primiparae. Br J
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MA, Ibrahim AK (2016) Fractional CO2 laser versus intense pulse light in
treating striae distensae. Indian J Dermatol 61:174-180.
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Aginaa HA, Sorour NE (2015) Microneedling system alone versus microneedling
system with trichloroacetic acid in the management of abdominal striae rubra: A
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Savas JA,
Ledon JA, França K, Nouri K (2013) Lasers and lights for the treatment of
striae distensae. Lasers Med Sci 29: 1735-1743.
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Kim BJ,
Lee DH, Kim MN, Song KY, Cho WI, et al. (2008) Fractional photothermolysis for
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rubra. J Cutaneous Aesthet Surg 9: 101-105.
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Fatemi F,
Behfar S, Abtahi-Naeini B, Keyvan S, Pourazizi M (2016) Promising option for
treatment of striae alba: Fractionated microneedle radiofrequency in
combination with fractional carbon dioxide laser. Dermatol Res Pract 1-7.
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