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T cells are classified as Th1/Th2 depending upon activation
marker and cytokine production. Activated T-cells in circulation causes
increased infiltration of leukocytes into vasculature leading to stress induced
hypertension Activated T cells which infiltrate into kidney producing cytokine
promotes sodium and water retention leading to overt hypertension. Monocytes
are capable of producing antigen to T-cells, thus, monocyte depletion is
prevention of T-cell activation preventing the etiopathogenseis of gestational
hypertension. Th17 cells newly deducted subset of T-cells which produce
cytokine IL-17. It has a major role in autoimmune disease, obesity and
cardiovascular diseases.
We are reporting case series of 8, conducted in ESIMC
PGIMSR, Bangalore for one year during the period of 2018-2019, with 5 cases of
primigravida and 3 cases of multigravida with age from 20-34, who presented
with history of hypertension and its adverse fetal outcome.
Conclusion:
Proper analysis, prevention and treatment are necessary to have better fetal
outcome in patient with hypertension.
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