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Creature cells can be,
naturally, directed to be died, in a programmed process of cell death, or so
called: cell suicide. This process is a phenomenon, which is concerning with
the natural characteristic situation of the length of the telomere, of DNA, in the
cell. Where, at critical length of the telomere, the DNA [and the cell itself],
is not continuing, any more, in the process of replication, to prevent facing
any genetic structure changes. Accordingly, cancer cells are not directed to be
died, as their telomere, of DNA, is not going to approach a critical shortening
length of the shape situation.
INTRODUCTION
The phenomenon of cell death is one of the
important subject, which been given a lot of attention, in biological and
medical aspects.
There are, two main ways for the cells to be
vanished, [died]: either cells die by been damaged, [in variety of methods], or
the cells died by their own plan to kill themselves [1].
The planned way of the cells killing
themselves, is a programmed way and it is called [cell suicide]. The cell,
then, kills itself through internal processes program.
This programmed method of the cell killing
themselves is shown under a way of Apoptosis: where apoptosis is a normal
phenomenon, occurring frequently in a multi-cellular organism.
Apoptosis, sometimes called "cellular
suicide," is a normal, programmed process of cellular self-destruction.
Even though it involves cell death, apoptosis serves a healthy and protective
role in our bodies [2].
Also, apoptosis occurs normally during
development and aging and as a homeostatic mechanism to maintain cell
populations in tissues [3].
The apoptosis is the method, by which, most
cells been died. It is found that the process of cell death is of importance to
the creature for future life.
Cells death, [by programming], are for many
purposes as to: removing excess cells, create a structure in the body; get rid
of extra cells, when cells are damaged, or as cells are infected by viruses
[1].
For this reason, it is said that: Programmed
cell death is an essential part of staying healthy. At the process of cell
suicide program [apoptosis]: the cell shrinks, smaller in size, and condenses
[4]. Also, the nuclear DNA breaks up into fragments. The cell death
without damage to its neighbouring cells.
For Cancer cells often resist cell death, even
after anti – cancer treatment [4].
As it is shown that: Programmed cell death is
an essential part of staying healthy, however, when the process goes haywire,
it promotes the growth of cancer [5]. Sometimes, there is not enough cellular
suicide, especially in the case of cancer.
Cancers are talented at avoiding death and have
sophisticated mechanisms that hijack components of the auto-phagy, apoptosis,
and necrosis signalling pathways. When they spread through the body, cancers
escape cell death by deactivation these pathways [5].
If the DNA of a cell is damaged to a degree
where the cell is unable to repair itself - mechanisms will signal the cell to
kill itself, in order to prevent cancerous transformation. Malignant
melanoma cells can resist committing suicide when attacked by chemotherapy. The
explanation lies in the discovery that a key gene in the cell-death pathway is
switched off in this cancer [6].
An ability to avoid committing suicide is one of the
keys to a cancer cell's survival, whether it is spreading from one part of the
body to another by metastasis or facing attack from chemotherapy.
Generally, it shows that, it needs to have more
researches of explanation, to be done on cell death, as it seems that, there is
not, yet, respectively, a lot of research has been done.
DISCUSSION
It is believed that the occurrence of the cell
die [called: cell suicide], is caused concerning with the purpose of the
importance to save the fundamental of the original genes, [of the DNA
molecule], characteristics, for the exact certain creature.
The explanation can be shown, firstly, by
applying the conditions that: the telomere is shortening in each stage of DNA
replication, and that, the critical number of the telomere’s base pairs,
[telomere length], is causing the process of the DNA replication to be stopped,
until the cell been died.
Then, accordingly, the resulting process could
be discussed as the following:
Suppose that, if the DNA is going to be
continued to be replicated after the state of the critical length of the
telomere, then, this will show that, the next stage of DNA replication will be
caused to be:
Some of the DNA genes are going to be lost.
Where, these genes, are placed, to be nearest to the critical length of the
telomere, [as this case is concerning with the shortening process of the
telomere, in each replication].
Therefore, it shows that, this process, [if it
is happened], will leave the replicated, [new], DNA molecule, [and then the
cell, as a whole], to be totally different, in its genetic characteristics
formation, [inherently], than that of its original one, (as because some of
genes are lost from the original DNA structure construction).
This result will lead to that, the, [new], DNA
molecule is going to be belonging to a different sort of creature, [kind
living], and not to be to the same original one.
Hence, this will show that this creature will
hold some cells which are of different types of DNA structure, in its [same]
body. Therefore, this is not, [entirely], acceptable in the genetic structure
formation characteristics, of a creature body.
Accordingly, for the situation of the state of
the critical length of the telomere, of the DNA, the DNA should not going on to
be of any further future replication. This means that the DNA [and the cell
itself], are, now, in a process of having to finish the performing of their
life activity. Then, the lifelike occurrence of the body, is that to direct
these certain cells to be in the process of the dying action. This action could
be shown as it is created by the inherent of the creature itself.
Then, the dying process could be created by a
mechanism signal, as it is the right and firm action to prevent any up-normal
difficulties could be caused in the cell, [as that of the occurrence of
different type of genes in DNA].
In other words, it means that, the occurrence
of the process of the cell dying is the right, and healthy genetically, action,
to prevent any fundamental change could be happened, to the cells of the body,
for a certain creature.
Therefore, [at the stage level of the critical
length of the telomere of DNA], the death of the cell is of an importance,
which is exactly necessary for the original natural and right characteristics
of the creature.
Now, it could be discussed, as well, the
condition concerning with the cancer situation. It is fundamentally to show
that:
There is no cellular suicide for cancer cells.
This is true occurrence condition, and it is supporting the believe that just
been explained here. Which is for the reason behind the cell death [suicide]
occurring.
The explanation may be shown as the following:
The, main, condition of the cancer cells, is
that, the telomere, (of the DNA), is being lengthening, [after been shortened],
during each DNA replication process.
Then this situation leads to show that, there
will be not a certain, real, condition, [could be occurred], for a critical
length of the telomere, of DNA, in the cancer cell. Accordingly, there is not a
certain, [practical], reason to make the cancer DNA to loss any part of its
genes, or any of its characteristics.
Now, [ for cancer cells], as the telomere, of
the DNA, is not going to be in a state of the critical length condition, then,
this means that, there is not any certain reason to lead the cancer cells to
kill themselves, [i.e. to be in the cell suicide condition]. This is to show
that, as long as the telomere, of DNA, of a cancer cell is not going to be
shortening, then the DNA [and the cell], is going to be continued to be
replicated, for no limit number of times.
Also, as it is concerned with the matter of
cancer treatment, it is believed that, a right thoughtful can be applied as,
that, of the action of magnetism, [or electromagnetic action], in the aiming of
the possibility to cure cancer [7].
1. Eliz
Hall W (2017) Cell death, Institute of Medical Research.
2. Dutchen
S, Saltsman K (2011) Cell Suicide, An Essential Part of Life, National
Institutes of Health.
3. Elmore
S (2007) Apoptosis: A review of Programmed Cell Death. Toxicol Pathol 35: 495-516.
4. Kerr
JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with
wide – ranging implications in tissue kinetics. Br J Cancer 26: 329-357.
5. Hartman
B (2017) When Cell Death Goes Bad, Anti-Aging Science.
6. Jones
PA (2018) Cancer: Death and methylation. Int J Sci.
7. Rojeab
AY (2015) Novel strategy to cure cancer. Cancer Res J 3: 6-10.
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