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Seminal Plasma (SP) proteins are rich with
many proteins of different genital tract origin so the fields of proteomics
were promise for the development of novel male infertility biomarkers. Seminal
plasma proteins Testis Expressed Protein 101 (TEX101) and Extracellular Matrix
Protein 1 (ECM1) assay are already available or under final development for
clinical use, so the aim of study, evaluation of TEX101 and ECM1 Seminal Plasma
(SP) proteins for assessment the predictive of sperm retrieval rate (SRR) in
testicular sperm retrieval and diagnosis obstructive from non-obstructive
azoospermia.
A case control study was included 65
infertile azoospermic men were subjected to clinical examination, seminal fluid
analysis, hormonal investigation and SP proteins TEX101 and ECM1 assessment by
Enzyme Linked Immuno-Sorbent Assay (ELISA) as well as they were subjected to
the conventional Testicular Sperm Extraction (TESE) technique, mincing with
searching for sperm.
The result of study included mean age of 65
men were recorded 33.37 ± 6.99 years which were divided into 10 (15.38%)
obstructive type (OA) and 55 (84.62) non-obstructive (NOA) type. The SRR
account 36 out of 65 patients (55.4%) were divided into OA (100%) and NOA (47.3%)
and the difference was significant (P=0.014). The TEX101 and ECM1 were a
significantly (P<0.001 and P=0.007, respectively), higher in NOA than OA. The
receiver operating characteristic curve or ROC curve show that the SP TEX101
cut-off values above 0.9 ng/ml is candidate to sperm retrieval technique. The
ECM1 protein, the cutoff values (>943.11 pg/ml for differentiation of NOA
versus OA.
Keywords: Proteomics, TEX101, ECM1, Sperm retrieval technique, Reproductive
hormones, Testicular histopathology
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