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Asthenozoospermia
is a common cause of male infertility. It is characterized by reduced sperm
motility and has numerous cellular mechanisms. Unfortunately, there are
restricted data on dynein ATPase and ATPase associated with various cellular
activities (AAA)1-2. This study explored the role of dynein ATPase activity and
quantification of AAA1-2 dynein. Fifteen asthenozoospermia samples were used in
this study. Semen analysis was conducted based on WHO 2010, while dynein ATPase
was defined by the released inorganic phosphate and AAA was determined by
ELISA. This study showed that the dynein ATPase activity in asthenoozoospermia
was significantly lower than in the normozoospermia group (3.7 ± 0.3 vs. 7.5 ±
0.4 μmol Pi/mg protein/h, respectively, p<0.05). Furthermore, the
quantification of AAA1 and AAA2 was showed unsignificantly lower in
asthenozoospermia compared to normozoospermia group (1.7 ± 0.1 vs. 4.5 ± 0.2;
3.8 ± 0.4 vs. 5.6 ± 0.5 ng/ml, respectively, p>0.05). The structure and
function of damaged sperm dynein may alter dynein ATPase activity and levels of
AAA1 and AAA2 in asthenozoospermia.
Keywords: Dynein ATPase, AAA1, AAA2, Asthenozoospermia,
Male infertility
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