Research Article
Genetic Disease Repair (5p-) Through Coordination Dynamics Therapy I
Giselher Schalow*
Corresponding Author: Giselher Schalow, Untere Kirchmatte 6, 6207 Nottwil, Switzerland.
Received: February 16, 2023; Revised: March 12, 2023; Accepted: April 15, 2023 Available Online: April 26, 2023
Citation: Schalow G. (2023) Genetic Disease Repair (5p-) Through Coordination Dynamics Therapy I. Int J Med Clin Imaging, 9(1): 477-611.
Copyrights: ©2023 Schalow G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The 9.5-year-old patient Anna with severe cri-du-chat syndrome learned creeping, crawling, up righting, walking, running, jumping and climbing staircases through 4.1 months of rather optimal coordination dynamics therapy (CDT). The emotional pattern crying and laughing became operational. It is the first time that a real progress through therapy is published in this genetic disease. The lost piece of chromosome 5 included 5p15.1 through 5p15.33. Vojta, Bobath, and exercising on the “Locomat” did not improve Anna. Only low-intensity CDT at an age between 5.5 to 9.5 years made her walking a few steps. It cannot be excluded that with this optimal 4.1-months CDT at an age of 9.5 years, genetic plasticity started to take place and not only a repair of the malformed central nervous system (CNS) caused by pathologic development due to the genetic disease. This coordinated-movement-based learning therapy seemed to be capable of targeting the epigenome and altering gene expression and hence to repair the CNS in Anna, especially in the phase of super-coordination. The possibility of repair through gene expression changes is supported by CNS repair through CDT in traumatic brain injury, spinal cord injury, stroke, Parkinson, spina bifida, cerebral palsy, coma patients, bladder incontinence, basal ganglia injury, spinal muscular atrophy and cancer growth inhibition. Even though cognitive functions improved, Anna did not learn so far to speak, apart from the three words mama, tata and baba, and to read, write and calculate.

CDT was developed within 36 years on the basis of human repair-neurophysiology, including human anatomy, human neurophysiology and CNS repair data of human patients. The anatomy of the cauda equina nerve roots, down to teased nerve fiber dissections, were clarified to develop the single-nerve-fiber action potential recording method to measure simultaneously the natural impulse pattern of single-nerve fibers running in and out of the CNS and analyze human CNS functioning. With the discovered phase and frequency coordination among neurons for neural network organization, which becomes impaired following injury, malformation and degeneration, CDT was developed to repair the impaired phase and frequency coordination and induce plasticity by using coordinated movements from phylogeneses and ontogenesis. By combining human repair-neurophysiology with the System Theory of Pattern Formation and using a special CDT device for coordination treatment and measurements of arm and leg movements, the progress in CNS repair could objectively be quantified by a single-coordination dynamics value, which could be compared with existing values of healthy children.

Keywords: Human repair-neurophysiology, Single-nerve fiber action potentials, Neural network organization, Phase and frequency coordination, System theory of pattern formation, Coordination dynamics therapy, Continence, Genetic disease repair, Super-coordination phase
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