Immunological Role in Hypertension
Manasa GV* and Sreelatha S
Corresponding Author: Dr. Manasa GV, Junior Resident, Department of OBG., ESIC-MC PGIMSR, Bangalore, Karnataka, India
Published: August 10, 2019;
Citation: Manasa GV & Sreelatha S. (2019) Immunological Role in Hypertension. J Immunol Res Ther, 4(S1): 12.
Copyrights: ©2019 Manasa GV & Sreelatha S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

T cells are classified as Th1/Th2 depending upon activation marker and cytokine production. Activated T-cells in circulation causes increased infiltration of leukocytes into vasculature leading to stress induced hypertension Activated T cells which infiltrate into kidney producing cytokine promotes sodium and water retention leading to overt hypertension. Monocytes are capable of producing antigen to T-cells, thus, monocyte depletion is prevention of T-cell activation preventing the etiopathogenseis of gestational hypertension. Th17 cells newly deducted subset of T-cells which produce cytokine IL-17. It has a major role in autoimmune disease, obesity and cardiovascular diseases.

We are reporting case series of 8, conducted in ESIMC PGIMSR, Bangalore for one year during the period of 2018-2019, with 5 cases of primigravida and 3 cases of multigravida with age from 20-34, who presented with history of hypertension and its adverse fetal outcome.

Conclusion: Proper analysis, prevention and treatment are necessary to have better fetal outcome in patient with hypertension.


Keywords: Pre-eclampsia, Gestational hypertension, IUD, T-cells, Monocytes