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Extensive findings have approved this hypothesis. For example, in a study by Hornig et al.  a number of neurological disorders were discovered in an autoimmune disease-sensitive mouse strain exposed to THIM. Similarly, Hewitson et al.  explained that monkeys infant exposed to THIM-containing hepatitis B vaccine showed a delay in getting of some survival, motor and sensorimotor reflexes. In another behavioral study, it was revealed that neonatal exposure to THIM can make abnormal social interactions, stereotyped behaviors and locomotors activity comparable to those detected in neurodevelopmental disorders .
In conclusion, all these findings support a theory that THIM has many negative effects on CNS and immune system and may reason neurotoxic changes in the developing brain, which is a powerful reason for eliminating this unnecessary component from vaccines and other medicinal products.
1. Bernard S, Enayati A, Roger H, Binstock T, Redwood L (2002) The role of mercury in the pathogenesis of autism. Mol Psychiatry 7: 42.
2. Duszczyk-Budhathoki M, Olczak M, Lehner M, Majewska MD (2012) Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: Protective role of dehydroepiandrosterone sulfate. Neurochem Res 37: 436-447.
3. Olczak M, Duszczyk M, Mierzejewski P, Meyza K, Majewska MD (2011) Persistent behavioral impairments and alterations of brain dopamine system after early postnatal administration of thimerosal in rats. Behav Brain Res 223: 107-118.
4. Chen YN, Wang J, Zhang J, Li SJ, He L, et al. (2013) Effect of thimerosal on the neurodevelopment of premature rats. World J Pediatr 9: 356-360.
5. Kern JK, Geier DA, Audhya T, King PG, Sykes LK, et al. (2012) Evidence of parallels between mercury intoxication and the brain pathology in autism. Acta Neurobiol Exp 72: 113-153.
6. Namvarpour Z, Nasehi M, Amini A, Zarrindast MR (2018) Protective role of alpha-lipoic acid in impairments of social and stereotyped behaviors induced by early postnatal administration of thimerosal in male rat. Neurotoxicol Teratol 67: 1-9.
7. Barrett JR (2005) Thimerosal and animal brains: New data for assessing human ethyl mercury risk. Environ Health Perspect 113: A543A544.
8. Burbacher TM, Shen DD, N. Liberato N, Kimberly SG, Elsa C, et al. (2005) Comparison of blood and brain mercury levels in infant monkeys exposed to methyl mercury or vaccines containing thimerosal. Environ Health Perspect 113: 1015-1021.
9. Magos L, Brown AW, Sparrow S, Bailey E, Snowden RT, et al. (1985) The comparative toxicology of ethyl and methyl mercury. Arch Toxicol 57: 260-267.
10. Gasset AR, Itoi M, Ishii Y (1975) Teratogenicities of ophthalmic drugs: II. Teratogenicities and tissue accumulation of thimerosal. Arch Ophthalmol 93: 52-55.
11. Mutter J, Naumann J, Schneider R, Walach H, Haley B (2005) Mercury and autism: Accelerating evidence? Neuroendocrinol Lett 26: 439-446.
12. Olczak M, Duszczyk M, Mierzejewski P, Bobrowicz T, Majewska MD, et al. (2010) Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. Neurochem Res 35: 1840-1847.
13. Rampersad GC, Suck G, Sakac D, Fahim S, Foo A, et al. (2005) Chemical compounds that target thiol‐disulfide groups on mononuclear phagocytes inhibit immune mediated phagocytosis of red blood cells. Transfusion 45: 384-393.
14. Afsordeh K, Sadeghi Y, Amini A, Zahra N, Amin M, et al. (2019) Alterations of neuroimmune cell density and pro-inflammatory cytokines in response to thimerosal in prefrontal lobe of male rats. Drug Chem Toxicol 42: 176-186.
15. Laurente J, Remuzgo F, Ávalos B, Chiquinta J, Ponce B, et al. (2007) Neurotoxic effects of thimerosal at vaccines doses on the 'encephalon and development in 7 days old hamsters. An Fac Med Lima 68: 222-237.
16. Namvarpour Z, Amini A, Nasehi M, Zarrindast MR (2018) The effects of early exposure to thimerosal on impairments of social and stereotyped behaviors and the number of Purkinje cells of cerebellum in rats. Appl Biotechnol Rep 5: 105-111.
17. Hornig M, Chian D, Lipkin WI (2004) Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol Psychiatry 9: 833.
18. Hewitson L, Lopresti BJ, Stott C, Mason NS, Tomko J (2010) Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study. Acta Neurobiol Exp 70: 147-164.
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