Abstract
Urine Antigen Tests in the Etiological Diagnosis of Community Acquired Pneumonia - Our Experience
Marina Roksandić Milenković*, Vesna Ćeriman, Vladislav Milenković and Dragana Jovanović
Corresponding Author: Marina Roksandić Milenković, Faculty of Medicine, University of Belgrade, Serbia
Accepted: May 01st, 2020
Citation: Milenković MR, Ćeriman V, Milenković V & Jovanović D. (2020) Urine Antigen Tests in the Etiological Diagnosis of Community Acquired Pneumonia - Our Experience. J Pharm Drug Res, 3(S1): 07.
Copyrights: ©2020 Milenković MR, Ćeriman V, Milenković V & Jovanović D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share :

Introduction: European, British and American guidelines for diagnosis and treatment of community-acquired pneumonia (CAP), recommend the use of imunochromatographic urine antigen tests for Streptococcus pneumoniae and Legionella spp., for all patients with moderate to severe, i.e., very severe CAP.

Objective: Evaluation of the efficiency of the urine antigen tests in the etiological diagnosis ofcommunity acquired pneumonia in our conditions.

Materials & Methods: It has been tested non concentrated urine of 18 patients with clinically and radiologically confirmed diagnosis of CAP, hospitalized in the Clinic of Pulmonology, Clinical Center of Serbia, using imunochromatographic Binax NOW urine antigen tests for Streptococcus pneumoniae and Legionella spp. Testing was done on the first day after admission to the hospital. In all patients, bacteriological tests of sputum was done. It was determined the specificity, sensitivity and diagnostic accuracy (efficiency) of the tests.

Results and Discussion: The urine antigen test for Streptococcus pneumoniae was positive in 4 (27%) of non concentrated urine sample of patients. Test for Legionella spp. was negative in all tested samples. Bacteriological examination of sputum shows that Streptococcus pneumoniae was isolated in 5 (28%) patients, while one patient has isolated Pseudomonas aeruginosa. The sensitivity of the urine assay for antigen Streptococcus pneumoniae, was 60% and the specificity was 92%. The efficiency of the test was 94%. The specificity of the test for Legionella spp. was 100%. The sensitivity of the test was not possible to reliably estimate because of Legionella infection is not confirmed in any of the respondents. The efficiency of the test was 100%.

Conclusion: Due to the speed and ease of execution and good specificity of these tests, justified their use in everyday work for better orientation and selection of adequate therapy. On the other hand, the relatively low sensitivity of imunochromatographic urine antigen tests, especially for Streptococcus pneumoniae, as well as their high economic price, call into question the justification for the use of these tests in daily clinical practice. Due to the limited number of available tests in our conditions and a relatively small number of tested subjects, additional tests are needed for adequaate assessment.