• 10/04 Assistant Professor, Department of Internal Medicine, Division of Geriatric and Palliative Medicine, and Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA • 02/12 Associate Professor with tenure, Department of Internal Medicine, Division of Geriatric and Palliative Medicine, and Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, USA • 08/13 Adjunct Associate Professor, Department of Biological Science, Wayne State University, Detroit, USA • 08/13 Professor, Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taiwan • 02/17 Acting Director, Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taiwan • 02/18 Professor, Institute of New Drug Development, China Medical University, Taiwan • 02/18 Director, Research Center of Excellence for Healthy Aging, China Medical University, Taiwan

1. Role of Heat-Shock Factor (HSF-1), histone, and Sirtuin in stress response and aging. 2. Molecular mechanisms of the longevity response to dietary restriction (DR). 3. Inter-organ and inter-cell communications that mediates the longevity regulation. 4. Cellular mechanisms of age-associated decline of motor activity and cognitive function. 5. Identification and characterization of small molecules that slow aging.