Editorial Board

Dr. Muhsin Jamal, PhD

Dr. Muhsin Jamal, PhD
Assistant Professor
Department of Microbiology,
Abdul Wali Khan University
Pakistan

Biography :

Dr. Jamal has earned his PhD degree in microbiology form National University of Sciences & Technology (NUST), Islamabad, Pakistan, in collaboration with University of Florida (UF), USA (since September, 2015). Dr. Jamal is currently working as Assistant Professor at Department of Microbiology, Abdul Wali Khan University, Mardan, Pakistan (since November, 2015). Dr. Jamal has been worked as Head of the Department for about one year and is also serving as co-ordinator for the Board of studies of the department. He has published about 30 publications in international well reputed journals and has also developed several courses at graduate and postgraduate levels. Dr. Jamal is actively involved in research work and has completed a project on bio-control of Pseudomonas areoginosa and have submitted several project related to bio-control of food and control of pathogenic bacteria. Moreover, Dr Jamal is working as editorial board member for two journals and also working as reviewer for several journals such as Medicine, Befouling and some other journals. In the next 5 years Dr. Jamal is hoping to be among the leading researchers in Pakistan and also holding good position in the international scientific community.

Research Interest :

Bacteriophage therapy : Bacteriophages or "phages" are viruses that invade bacterial cells and, in the case of lytic phages, disrupt bacterial metabolism and cause the bacterium to lyse [destruct]. Phage Therapy is the therapeutic use of lytic bacteriophages to treat pathogenic bacterial infections. We are interested in isolation of bacteriophages from various sources (such as e.g. soil, river, springs, waste water , animal and animal waste) against various multi-drug resistant bacteria ( such Escherichia coli , Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella speeses , Listeria, monocytogenes, Campylobacter, Shigella dysenteriae, Kliebsilla pneumonia, Enterobacter cloacae ) and studying various characteristics of such phages having a key role in phage therapy. These phages are characterized for its various characteristics such as Host range, One step growth (burst size and latent time), Heat stability, pH stability, Calcium/Magnesium on effect on phage adsorption to host, Phage morphology by transmission electron microscopy, Phage genome isolation/ sequencing and proteins Analysis. Formulation of different potencies of phages and studying their deleterious effect on their respective host bacterial strains in planktonic forms (liquid culture) at specific temperature and pH. And finally formation of phage cocktail (combination of different phages) to avoid bacterial resistance and studying their deleterious effect on targeted bacterial strains at specific temperature and pH. Biofilm control using Bacteriophages: Biofilm is an association of micro-organisms in which microbial cells adhere to each other on a living or non-living surfaces within a self-produced matrix of extracellular polymeric substance. Bacterial biofilm is infectious in nature and can results in nosocomial infections. According to National Institutes of Health (NIH) about about 65% of all microbial infections, and 80% of all chronic infections are associated with biofilms. Nearly all (99.9%) of micro-organisms have the ability to form biofilm on a wide range of surfaces i.e. biological and inertsurfaces. When micro-organisms bind to a surface, they produce extracellular polymeric substance (EPS) and form biofilm. Biofilm posing a great problem for public health due to its resistant nature to antibiotics and disease associated with indwelling medical devices. We are also interested in studying various bacterial strains tendency for biofilm formation on various material surfaces ( such as 96- ell plates, petriplates, plastics, rubbers, stainless steel plates and test tubes and also to treat /control such types of biofilms using host specific bacteriophages and phage cocktails. Food Bio-safty: Food borne illness of microbial origin continues to be a serious food safety problem worldwide. The Centers for Disease Control (CDC) has estimated1 that food borne pathogens cause approximately 76 million illnesses and 5,000 deaths each year in the United States alone. At the present time, the leading causes of death due to food borne bacterial pathogens are Listeria and Salmonella, followed closely by other food borne pathogens such as Escherichia coli (E. coli O157:H7, in particular) and Campylobacter jejunii. Bacteriophages may provide a natural, non-toxic, safe, and effective means for significantly reducing or eliminating contamination of foods with specific pathogenic bacteria, thereby eliminating the risk, or significantly reducing the magnitude and severity, of food borne illness caused by the consumption of foods contaminated with those bacteria. We are also involved in isolation of bacteriophages against bacteria causing food spoilage and food born infections. In this concern we are focusing on Listeria, Salmonella, Escherichia coli (E. coli O157:H7, in particular) and Campylobacter jejunii. Bacterial antibiotic resistance: Antibiotic resistance is rising to dangerously high levels in all parts of the world. New resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases. A growing list of infections – such as pneumonia, tuberculosis, blood poisoning and gonorrhoea – are becoming harder, and sometimes impossible, to treat as antibiotics become less effective. Without effective antimicrobials for prevention and treatment of infections, medical procedures such as organ transplantation, cancer chemotherapy, diabetes management and major surgery become very high risk. Antimicrobial resistance increases the cost of health care with lengthier stays in hospitals and more intensive care required. Antimicrobial resistance is putting the gains of the Millennium Development Goals at risk and endangers achievement of the Sustainable Development Goals. We are interested in studying drug resistance in different bacterial isolates isolated from hospitals such as Escherichia coli , Pseudomonas aeruginosa, Streptococcus pneumonia, Staphylococcus aureus, Salmonella species , Shigella dysenteriae, Kliebsilla pneumonia, Enterobacter cloaca and Acenetobacter. We are focusing on molecular mechanisms of antibiotics resistance and also other factors which contribute to resistance in bacteria.

 
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