Editorial Board

Dr. Sandeep Singh, PhD

Dr. Sandeep Singh, PhD
Researcher
Department of Neurobiology
University of Chicago
USA

Biography :

I had worked as Senior Research Fellow at National Bureau of Agriculturally Important Microorganisms (NBAIM) on a Network Project entitled ”Application of Microorganisms in Agriculture and Allied Sectors (AMAAS)”, sub theme-“Microbial Diversity” with main emphasis on “Diversity analysis of thermophilic fungi”.

Research Interest :

My research interests involve the role of gut microflora and neuro-inflammation in progression of Alzheimer’s disease (AD). My PhD. research project, focused on the study of therapeutic potential of some synthetic as well as herbal compounds against amyloid beta toxicity in AD using drosophila as a transgenic AD model. These studies led to the publication in esteemed peer-reviewed neuroscience journals. I also used some metal chelators (Copper chelator) to prevent copper mediated amyloid beta toxicity in drosophila model system. I am currently employed as a postdoctoral scholar at the University of Chicago. In this new role I currently focus on the role of microbial immune responses in AD pathogenesis. Using a highly collaborative research approach, involving principal investigators from over the USA, I have induced perturbations in the gut microbiome of AD transgenic mice and investigated alterations in innate immunity and amyloidosis. These ongoing studies will significantly impact the research field and continue to explore the largely unknown contribution of commensal microbes in health and disease. I have significant experience in animal work (establishing transgenic drosophila lines, handling of transgenic mice model, oral gavage and injection treatments, behavioural testing and analysis, anesthesia, cardiac perfusion) including other laboratory techniques like; Isolation of DNA and RNA, Electrophoresis (SDS-PAGE & Agarose), Western Blotting, Screening of Microbes from Different Samples, PCR/RT-PCR, immunohistochemistry and Immunofluorescence. UV-Vis spectrophotometry, Fluorescence, Confocal and Scanning Electron Microscopy, histology etc. Work conducted during my 3rd year of PhD has been presented at the 13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, March 26-29, 2014, Geneva, Switzerland. For presenting my work there I got travel award from Indian Council of medical research (ICMR). Apart from this symposium, I also presented my PhD work in various national and International conferences.