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Background: Male infertility proves to be a
psychological distress for the married couples. Numerous research studies have
attempted to determine the causes of male infertility with the objective of
developing therapeutic approaches to effectively improve various semen
parameters. The presented intervention is a quantitative approach that
categorically assesses the therapeutic advantage of oral GSH (glutathione)
administration on various semen parameters including sperm concentration,
morphology and motility in infertile males. The study hypothesis presumes the positive/linear
correlation of the selected sperm parameters with orally administered
glutathione.
Materials and
methods: The prospective placebo-controlled study included 101 infertile
adult males through random selection between the timeframe of January 2017 to March 2018. The selected
subjects did not experience any chronic disease of the reproductive system and
exhibited normal female factor. GSH oral therapy was administered between 0 to
6 months,
51 patients recieved GSH therapy and 50
patients received Placebo in the form of glucose sachets. At the time of 0, 3 and 6 months blood and
semen samples were taken for analyses for treatment and placebo groups.
Results: The findings recorded at 0 weeks, 3 months,
and 6 months interval revealed a significant p-value (between 0.01 to 0.03 for
sperm motility, morphology and concentration). At 0 week no statistical
significance for the results while at 3 months GSH value was 4.55 mg/dL for GSH group therapy
in comparison for 1.55 mg/dL for placebo group which was statistically
significant.
Keywords: Oral GSH, Male
infertility, Glutathione, Sperm concentration, Sperm morphology, Sperm motility
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