|Yun-Qiao Li and Xuan Guo*|
|Corresponding Author: Xuan Guo, Research Institute of Chemical Defense, State Key Lab of NBC Protection for Civilian, No. 1 Huaiyin Road, Beijing, China|
|Received: May 10, 2018; Accepted: June 2, 2018; Published: November 26, 2018;|
|Citation: Li Y Q & Guo X. (2018) Direct-Acting Antiviral Agents are Urgently Needed in China. Adv Vaccines Vaccin Res, 1(1): 1-2.|
|Copyrights: ©2018 Li Y Q & Guo X. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Keywords: Hepatitis C virus; Chronic hepatitis C; Direct-acting antiviral agents
Hepatitis C virus (HCV) infection is one of the most common hepatic diseases, which could pose a public health threat to the world. In China, there are more than ten million patients infected by HCV . The treatment system for HCV infection has changed drastically over the past 5 years, direct-acting antiviral agents (DAAs) has stepped onto the historical stage and experienced unprecedented development with a real breakthrough [2,3]. In fact, when the pegylated interferons α-ribavirin was widely used to treat HCV infection, we have already realized that there was a possibility of being cured after infected by HCV.
Although using the oral antiviral drugs has become the major treatment option in most developed countries, DAAs are not available in China. The most common treatment still based on the use of pegylated interferons α-ribavirin. However, the cure rate of this treatment could only achieve 44% to 70% . The recurrence rate for genotype 1b could even reach 10%. And it also has many side effects such as the long course of treatment, parenteral administration and the complicated operation. Moreover, for many patients with nephrosis or severe cirrhosis, such interferons are not allowed to be used. These limits towards interferons greatly hindered the patient's recovery and cure. With the development of economy, many of the domestic patients try to buy the DAAs from overseas in various ways. Unfortunately, these purchasing channels could not ensure the medicine quality, which could lead to the heavy potential safety hazard.
Zepatieris called as the “binary star” combination for curing HCV infection. It is a kind of combination drug of elbasvir and grazoprevir. The patients should take one pill every day for sustaining 12 weeks. This treatment would not need to combine ribavirin, which provides a much more convenient therapeutic schedule with only one single tablet. Meantime, for the HCV infection patients with other diseases such as cirrhosis, HIV, advanced chronic kidney disease and hereditary blood disease, Zepatier treatment could also get satisfactory efficacy when combined with other common clinical drugs.
All authors have contributed to this article. YQLdrafted the full manuscript and XG contributed in editing the manuscript.
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